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1-Pyrrolidinecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester




Molecular Formula:C9H15NO3

Molecular Weight:185.2203

UN Number:

Haz Class:

Packing Group:

Synonyms: N-Boc-3-pyrrolidinone; 101385-93-7; 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester; FT-0081994; FT-0601516; ST50827414; AZ0001-0468; B-1561; B35761; W-3873; MFCD01631194 (97+%); 1,1-Dimethylethyl 3-Oxo-1-Pyrrolidinecarboxylate; 1,1-dimethylethyl 3-oxo-pyrrolidine-1-carboxylate; tert-Butyl 3-oxopyrrolidinecarboxylate; 1,1-Dimethylethyl 3-oxopyrrolidine-1-carboxylate; 3-oxo-pyrrolidin-1-carboxylic acid t-butyl ester; 385B937; I11-0011; Q-102178; 101385-93-7 tert-butyl 3-oxopyrrolidine-1-carboxylate; F0001-0062; 3-oxo-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester; N-Boc-3-pyrrolidinol; C9H15NO3; 1-(tert-butoxycarbonyl)-3-pyrrolidinone; AR-1L6166; CID471360; n-(tert-butoxycarbonyl)-4-piperidone; ACN-038083; N-Boc-3-pyrrolidinone, 98% - 1G 1g; A16274; 10148-98-8; 14891-10-2; 79099-07-3; N-Boc-3-pyrrolidinone, 97%; 1-Pyrrolidinecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester; 1-tert-Butoxycarbonyl-3-pyrrolidone; n-tert-butoxycarbonyl-3-pyrrolidinone; 3-Oxopyrrolidine-1-carboxylic Acid tert-Butyl Ester; Boc-PN; N-boc-4-pyrollidone; 1-Boc-3-pyrrolidinone; N-Boc-3-pyrrolidone; PubChem9340; tert-butyl-3-oxopyrrolidin-1-carboxylat; AC1LAMXU; 1-Boc-3-pyrollidinone; ACMC-1BPVG; 1-Boc-3-Oxopyrrolidine; 1-N-boc-3-pyrrolidone; n-t-boc-3-pyrrolidinone; AC1Q1MWJ; tert-butyl 3-oxopyrrolidine-1-carboxylate; N-BOC-pyrrolidin-3-one; KSC174O0D; SCHEMBL123032; Jsp000212; CTK0H4701; DTXSID90332887; 3-oxopyrrolidine, n-boc protected; JSOMVCDXPUXKIC-UHFFFAOYSA-N; HT449; 1-t-butoxycarbonyl-3-pyrrolidinone; 1-N-Boc-3-pyrrolidinone; ACN-S003601; ACT01730; BCP22270; N-(t-butoxycarbonyl)-3-pyrrolidone; ZINC4202590; 1-(t-butoxycarbonyl)-3-pyrrolidone; 1-t-butoxycarbonyl -3-pyrrolidinone; n-tert-butoxylcarbonyl-3-pyrrolidone; ANW-14460; BBL001605; N-(tert-Butoxycarbonyl)-3-pyrrolidinone; CB-882; CT0162; FC0529; RW1280; RW2986; SBB056153; STL110020; 1-(t-butoxycarbonyl)pyrrolidin-3-one; 1-tert-Butoxycarbonyl-3-pyrrolidinone; 1-tert-butoxycarbonyl-3-oxopyrrolidine; n-boc-pyrrolidine-3-one; AKOS005145826; AC-6384; AN-1334; CM14269; CS-W020368; LS20699; MCULE-6399325930; PS-8499; QC-1766; RP24536; MFCD01631194; RTC-060787; SB10003; TRA0045045; 1-(t-butoxycarbonyl)-3-oxo-pyrrolidine; 1-(tert-butoxylcarbonyl)-3-pyrrolidone; 1-tert-butoxycarbonyl-3-oxo-pyrrolidine; KS-000002M1; 1-(tert-butoxyl carbonyl)-3-pyrrolidone; tert-butyl3-oxopyrrolidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-oxopyrrolidine; boc-3-pyrrolidinone; AJ-48462; AK-21882; BC208938; BR-21882; BR-44543; CJ-11439; SC-00080; SY001202; tert-butyl 3-oxo-1-pyrrolidinecarboxylate; tert-butyl-3-oxopyrrolidine-1-carboxylate; 1-boc-3-pyrrolidone; TL806112; 1-(tert-butyloxycarbonyl)pyrrolidin-3-one; AB0000669; AB1001166; DB-005460; ST1030152; TC-060787; tert-butyl-3-oxo-pyrrolidine-1-carboxylate; AM20070664; B3589;

Keywords: 101385-93-7,MFCD09749952,1P0004TA,1-Pyrrolidinecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester,C9H15NO3

Catalog# Purity Size Price Dis. Price Availability Quantity
1P0004TA 97% 1g $7.00 $5.00 In Stock USA ADD TO CART BUY NOW
1P0004TA 98% 5g $9.00 $7.00 In Stock USA ADD TO CART BUY NOW
1P0004TA 98% 10g $10.00 $8.00 In Stock USA ADD TO CART BUY NOW
1P0004TA 95% 100g $66.00 $49.00 In Stock USA ADD TO CART BUY NOW
1P0004TA 95% 250g $155.00 $116.00 In Stock USA ADD TO CART BUY NOW

  • 1-Pyrrolidinecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester, often known by its more common name, N-Boc-3-pyrrolidinone, is an organic compound that plays a crucial role in modern chemical synthesis. This compound is a derivative of pyrrolidinone with the tert-butyl carbamate (Boc) group offering protection for the amine, and a keto functionality on the pyrrolidine ring.
    One of the primary applications of N-Boc-3-pyrrolidinone is in the synthesis of pharmaceuticals and bioactive molecules. Its protected amine can undergo various chemical reactions without interference from the amine group, which is crucial for building complex molecules in a controlled and stepwise manner.
    Moreover, the keto group on the pyrrolidine ring can participate in various condensation reactions such as with hydrazines, hydroxylamines, or semicarbazides to form the corresponding pyrrolidinone derivatives, which can be further transformed into a wide range of heterocyclic compounds.
    The Boc group itself can be removed under acidic conditions, allowing for selective deprotection and further functionalization of the amine in later stages of a synthetic sequence. This attribute is particularly useful in peptide synthesis, where the amine group can be protected while other amino acid residues are coupled.
    Another critical application of N-Boc-3-pyrrolidinone is in asymmetric synthesis. The chiral environment of the pyrrolidinone ring can induce stereochemistry in subsequent reactions, which is essential in the creation of chiral centers for pharmacologically active substances. Keto-enol tautomerism of the keto group can be exploited in such enantioselective reactions.
    Furthermore, the compound is often used in the development of protease inhibitors, a class of drugs that are used to inhibit the function of proteases (enzymes that break down proteins) and have applications in the treatment of diseases like HIV and Hepatitis C.
    In total, N-Boc-3-pyrrolidinone's versatility in providing both a protected amine and a reactive keto group, alongside its utility in promoting chirality, makes it an invaluable building block in the synthesis of complex organic molecules. It's a testament to the intricate ballet of protecting groups and functional group interplay that is central to the craft of synthetic organic chemistry.

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