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10199-89-0
2,1,3-Benzoxadiazole, 4-chloro-7-nitro-

Catalog#:1P0006ND

CAS:10199-89-0

MDL:MFCD00005808

Molecular Formula:C6H2ClN3O3

Molecular Weight:199.5514

UN Number:

Haz Class:

Packing Group:

Synonyms: 4 Chloro 7 nitrobenzofurazan; 4-Chloro-7-nitrobenzofurazan; Nitrobenzoxadiazole Chloride; 4-Chloro-7-nitrobenzofurazan, 98% - 1G 1g; 4-Chloro-7-nitrobenzofurazan; 10199-89-0; Nbd chloride; 4-Chloro-7-nitro-2,1,3-benzoxadiazole; 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole; NBD-Cl; 2,1,3-Benzoxadiazole, 4-chloro-7-nitro-; 7-Chloro-4-nitrobenzofurazan; 1-Chloro-4-nitrobenzoxadiazole; 7 Chloro 4 nitrobenzofurazan; NBD-chloride; NBD-C 1; 4-Nitro-7-chlorobenzofurazan; 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole; BENZOFURAZAN, 4-CHLORO-7-NITRO-; 4-Chloro-7-nitrobenzo[c][1,2,5]oxadiazole; UNII-EQF2794IRE; NSC 228140; 4-chloro-7-nitrobenzo-2,1,3-oxadiazole; NBF-Cl; 7-Chloro-4-nitrobenzofurazan; Chloronitrobenzoxadiazole; EINECS 233-496-4; MFCD00005808; C6H2ClN3O3; BRN 0614212; EQF2794IRE; CHEBI:78878; IGHBXJSNZCFXNK-UHFFFAOYSA-N; NBD chloride, 98%; 4-chloro-7-nitrobenzo[c]1,2,5-oxadiazole; Chloride, NBD; 4-CHLORO-7-NITROBENZ-2-OXA-1,3-DIAZOLE; Shokat-update-comp17; nchembio866-comp17; Nitrobenzoxadiazole Chloride; AC1L18BR; SCHEMBL41754; 7-Nitro-4-chlorobenzofurazan; 4-Chloro-7-nitrobenzofurazane; 4-chloro-7-nitro-benzofurazan; 7-chloro-4-nitro-benzofurazan; Chloride, Nitrobenzoxadiazole; AMBZ0375; CHEMBL1743207; DTXSID2064995; SCHEMBL16305393; CTK8E4966; ALBB-020690; HY-D0042; ZINC1311094; 4-Chloro-7-nitrobenzofurazan, 98%; BBL011971; Chloronitrobenzoxadiazole; NSC228140; SBB005345; STK728793; AKOS000121286; ACN-048974; AM85450; CS-7530; MCULE-4610896893; NSC-228140; QC-1844; NBD Chloride; RTR-000476; 4-Chloro-7-nitro-benzoxa[1,3]diazole; UPCMLD0ENAT5654999:001; 4-chloro-7-nitro 2,1,3-benzoxadiazole; AC-24649; AJ-25370; AN-18285; LS-35358; ST033521; ZB016265; NBF Cl; 4-Chloro-7-nitro-2,1,3-benzoxadiazole #; AB1002860; TR-000476; EU-0033246; FT-0618144; ST24043626; 4-Chloro-7-nitro-benzo[c][1,2,5]oxadiazole; 199C890; 4-CHLORO-7-NITRO-BENZO[1,2,5]OXADIAZOLE; 7-CHLORO-4-NITROBENZ-2-OXA-1,3-DIAZOLE; NBF-Cl; SR-01000596972; I10-0827; J-100055; J-610037; SR-01000596972-1; 4-Chloro-7-nitro-1,2,3-benzoxadiazole; NBD-chloride; 4-Chloro-7-nitrobenzofurazan, BioReagent, suitable for fluorescence, >=97.0% (HPLC); C6-H2-Cl-N3-O3; CID25043; A5592;

Keywords: 10199-89-0,MFCD00005808,1P0006ND,2,1,3-Benzoxadiazole, 4-chloro-7-nitro-,C6H2ClN3O3

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Catalog# Purity Size Price Dis. Price Availability Quantity
1P0006ND 98% 100mg $16.00 $12.00 In Stock USA ADD TO CART BUY NOW
1P0006ND 98% 250mg $17.00 $13.00 In Stock USA ADD TO CART BUY NOW
1P0006ND 98% 1g $27.00 $20.00 In Stock USA ADD TO CART BUY NOW
1P0006ND 98% 5g $87.00 $65.00 In Stock USA ADD TO CART BUY NOW
1P0006ND 98% 10g $121.00 $91.00 In Stock USA ADD TO CART BUY NOW
1P0006ND 98% 25g $227.00 $171.00 In Stock USA ADD TO CART BUY NOW
1P0006ND 98% 50g $413.00 $310.00 In Stock USA ADD TO CART BUY NOW

  • 4-Chloro-7-nitrobenzoxadiazole, also known as 4-chloro-7-nitrobenz-2,1,3-oxadiazole or simply NBD-Cl, is a fluorescent dye that is particularly useful for the detection of amine-containing compounds. The molecule consists of a benzoxadiazole ring with electron-withdrawing nitro (NO2) and chloro (Cl) groups. These substituents are crucial for the reactivity and fluorescence properties of the compound.
    
    In chemical synthesis, NBD-Cl is commonly employed for the selective labeling of amine groups in both small molecules and biomolecules such as proteins and amino acids. When the molecule reacts with amines, it forms highly fluorescent derivatives, making it easy to track and quantify the presence of these groups with fluorescence spectroscopy.
    
    The reaction typically proceeds through nucleophilic substitution where the primary or secondary amine attacks the chloro group, displacing the chloride ion, and forms a stable cyclic amine derivative with the benzoxadiazole. This reactivity is exploited not only in pure chemistry but also in bioconjugation reactions where it is useful for labeling peptides, proteins, and other amine-presenting macromolecules for visualization and tracking purposes in various applications, including microscopy and flow cytometry.
    
    NBD-Cl is also useful in the preparation of pH sensors, as the fluorescence intensity of its derivatives can be pH-dependent, which allows for the development of tools that can monitor pH changes within different environments, such as cells or reaction mixtures.
    
    Lastly, the strong electron-withdrawing nature of the nitro group on NBD-Cl can make the molecule useful in the synthesis of more complex heterocyclic compounds through further reactions with nucleophiles, leading to the creation of diverse derivatives with potential applications in materials science and pharmaceuticals.

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