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Oxetane-3-carboxylic acid is a useful building block in chemical synthesis, particularly in the realm of pharmaceuticals and fine chemicals. Its four-membered oxetane ring introduces structural rigidity into molecules, which can influence the biological activity of the resulting compounds. This ring strain of the oxetane also makes it a useful component in ring-opening reactions that can be exploited in synthetic chemistry. One of the applications of oxetane-3-carboxylic acid is in the synthesis of beta-lactam antibiotics, where the oxetane ring can serve as a precursor to more complex four-membered ring structures found in many beta-lactam antibiotics. This is due to its structural similarity to the beta-lactam core, which is essential for the antibiotic's biological activity. Moreover, oxetane-3-carboxylic acid is also involved in the synthesis of peptidomimetics. The carboxylic acid group can participate in the formation of amide bonds, while the oxetane ring can mimic the backbone of peptides and influence the conformation of the peptidomimetic. This can lead to the discovery of compounds with improved stability and bioavailability compared to traditional peptides. Furthermore, it is used in creating prodrugs, where the oxetane ring can be enzymatically or chemically opened after administration to release an active drug. The latent reactivity of the oxetane ring's strained system facilitates this activation step within the body. Additionally, oxetane-3-carboxylic acid's derivatives have been explored in the design of potent inhibitors for a variety of enzymes. The oxetane ring's potential to enhance binding affinity through its conformational effects makes it an attractive feature in inhibitor design. In summary, oxetane-3-carboxylic acid is a versatile compound in organic synthesis, used to introduce rigidity into molecules, create new synthetic pathways, and improve the pharmacokinetic properties of bioactive compounds. Its application spans from antibiotic synthesis to the creation of enzyme inhibitors and the formulation of stable peptidomimetics.
oxetane-3-carboxylic acid
Catalog#:1P000AR0
CAS:114012-41-8
MDL:MFCD08669505
Molecular Formula:C4H6O3
Molecular Weight:102.0886
UN Number:
Haz Class:
Packing Group:
Keywords: 114012-41-8,MFCD08669505,1P000AR0,oxetane-3-carboxylic acid,C4H6O3
Inquire| Catalog# | Purity | Size | Price | Dis. Price | Availability | Quantity | ||
|---|---|---|---|---|---|---|---|---|
| 1P000AR0 | 97% | 100mg | $87.00 | $65.00 | In Stock USA | ADD TO CART | BUY NOW | |
| 1P000AR0 | 97% | 250mg | $100.00 | $75.00 | In Stock USA | ADD TO CART | BUY NOW | |
| 1P000AR0 | ≥95% | 1g | $102.00 | $77.00 | In Stock USA | ADD TO CART | BUY NOW | |
| 1P000AR0 | ≥95% | 10g | $754.00 | $565.00 | In Stock USA | ADD TO CART | BUY NOW |
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