Home > Products > 1445085-55-1

Palladium, [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][dicyclohexyl[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine](methanesulfonato-κO)-, (SP-4-3)-




Molecular Formula:C46H62NO3PPdS

Molecular Weight:846.4481

UN Number:

Haz Class:

Packing Group:


Keywords: 1445085-55-1,MFCD00063344,1P001K4G,Palladium, [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][dicyclohexyl[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine](methanesulfonato-κO)-, (SP-4-3)-,C46H62NO3PPdS

Catalog# Purity Size Price Dis. Price Availability Quantity
1P001K4G 98% 100mg $10.00 $8.00 In Stock USA ADD TO CART BUY NOW
1P001K4G 98% 250mg $14.00 $11.00 In Stock USA ADD TO CART BUY NOW
1P001K4G 98% 1g $27.00 $20.00 In Stock USA ADD TO CART BUY NOW
1P001K4G 98% 5g $105.00 $79.00 In Stock USA ADD TO CART BUY NOW
1P001K4G 98% 10g $200.00 $150.00 In Stock USA ADD TO CART BUY NOW
1P001K4G 98% 25g $498.00 $373.00 In Stock USA ADD TO CART BUY NOW

  • The palladium complex you've described, often referred to by the tradename SPhos, is a highly specialized ligand-modified palladium catalyst that is used in various cross-coupling reactions in organic chemistry. These reactions involve the joining of two different organic groups through a metal-mediated mechanism, which is fundamentally important for the construction of complex molecular architectures from simpler components.
    One of the most common applications of palladium-catalyzed cross-coupling is in the Suzuki-Miyaura reaction, which involves the coupling of aryl or vinyl boronic acids with aryl or vinyl halides or triflates. This reaction is widely used in the synthesis of various pharmaceuticals, agrochemicals, and organic materials due to its tolerance of a broad range of functional groups, its high selectivity, and the widespread availability of the starting materials.
    In the case of the SPhos palladium catalyst, its unique ligand structure allows for a highly efficient and selective coupling process, often at low catalyst loadings and under mild reaction conditions. This can be particularly valuable in the synthesis of complex and sensitive molecules, where the ability to selectively couple specific functional groups without affecting others is crucial. The chelating nature of the SPhos ligand helps stabilize the palladium center, thereby enhancing both the activity and the lifetime of the catalyst.
    Furthermore, this catalyst is known for its ability to facilitate challenging couplings, including those involving sterically hindered or electron-rich substrates, which might be problematic for less sophisticated catalysts. Its application has been successfully demonstrated in a variety of contexts, from small-scale laboratory synthesis to large-scale industrial processes.
    In terms of methodology, the use of the SPhos palladium catalyst typically involves the mixture of the relevant aryl halide or triflate and the boronic acid derivative in the presence of a base, with the catalyst being added to the reaction mixture followed by heating under an inert atmosphere to promote the coupling.
    In summary, the SPhos palladium catalyst represents an enabling technology in modern synthetic chemistry, facilitating the efficient and selective formation of carbon-carbon bonds, a fundamental transformation with wide-reaching implications across the chemical industry.

Copyright C 2019 1PlusChem LLC. All Right Reserved